Extracellular vesicles carrying miR-6836 derived from resistant tumor cells transfer cisplatin resistance of epithelial ovarian cancer via DLG2-YAP1 signaling pathway
Yazhu Zou, Zitong Zhao, Jingjing Wang, Liying Ma, Yi Liu, Li Sun, Yongmei Song
Abstract
Our study revealed the molecular mechanisms of chemotherapy resistance, and identified miR-6836 as the possible therapeutic target and effective biopsy marker for resistant EOC.
Topics & Concepts
CisplatinMicrovesiclesCancer researchmicroRNAOvarian cancerTumor microenvironmentExosomeCancer stem cellCancerBiologyChemotherapyMedicineInternal medicineTumor cellsGeneBiochemistryExtracellular vesicles in diseaseCancer-related molecular mechanisms researchCircular RNAs in diseases