Evaluation of the Diagnostic Performance of a Semiquantitative Cryptococcal Antigen Point-of-Care Assay among HIV-Infected Persons with Cryptococcal Meningitis
Kiiza Kandole Tadeo, Audrey Nimwesiga, Richard Kwizera, Lucy Apeduno, Emily Martyn, Michael Okirwoth, Elizabeth Nalintya, Radha Rajasingham, Darlisha A Williams, Joshua Rhein, David B. Meya, Bosco Kafufu, David R. Boulware, Caleb P Skipper
Abstract
= 0.084). The CrAgSQ demonstrates excellent diagnostic performance, maintaining both the sensitivity and specificity of the CrAg LFA, and counters false-negative prozone effects. The CrAgSQ assay reading is more complex but does provide useful clinical information about disease burden and probability of culture positivity in a single rapid diagnostic test.
Topics & Concepts
TiterMeningitisSerial dilutionCryptococcosisCerebrospinal fluidAntigenImmunologyMedicineLatex fixation testVirologyBiologyAntibodyPathologySurgeryAlternative medicineFungal Infections and StudiesAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatment