Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism
Jibao Zhu, Chengfei Hu, Zizhen Zeng, Xiaoyu Deng, Lingbing Zeng, Sai‐Sai Xie, Yuanying Fang, Yi Jin, Valérie Alezra, Yang Wan
Topics & Concepts
PolymyxinChemistryBacteriaAntibioticsAntibacterial activityPeptidePolymyxin BGram-negative bacteriaMicrobiologyGram-positive bacteriaAntimicrobialIn vivoAntibacterial agentLipopeptideBiochemistryBiologyEscherichia coliGeneGeneticsBiotechnologyAntimicrobial Peptides and ActivitiesAntibiotic Resistance in BacteriaImmune Response and Inflammation