Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Gefei Chen, Yuniesky Andrade‐Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska, Axel Abelein, Axel Leppert, Nina Kronqvist, Anna Rising, Hans Hebert, Philip J.B. Koeck, André Fisahn, Jan Johansson
Abstract
value between pH 6.0 and 7.0, suggesting that chaperone effects can be differently affected by physiological pH variations.
Topics & Concepts
NeurotoxicityFibrilChaperone (clinical)ChemistryResidue (chemistry)Protein aggregationAmyloid fibrilConserved sequenceBiophysicsBiochemistryAmyloid (mycology)Cell biologyAmyloid βPeptide sequenceBiologyDiseaseToxicityGeneInorganic chemistryOrganic chemistryPathologyMedicineProtein Structure and DynamicsEnzyme Structure and FunctionHeat shock proteins research