Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization
Jianye Li, Lu Yu, Yun Peng, Bin Chen, Rui Guo, Xiaodong Ma, Xiao‐Song Xue, Yunkui Liu, Guozhu Zhang
Abstract
-trig cyclization. Density functional theory calculations indicated that the tertiary radical intermediate was critical for the success of cyclization. In addition, the resulting saturated azetidine scaffolds possessed vicinal tertiary-quaternary and even quaternary-quaternary centers.
Topics & Concepts
ChemistryAzetidineRadicalRadical cyclizationVicinalCatalysisOrganic synthesisTandemAnnulationCascade reactionCombinatorial chemistryPhotoredox catalysisOrganic chemistryComposite materialPhotocatalysisMaterials scienceSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques