Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors
Sanahan Vijayakumar, Seyedmehdi H. Nasr, Jacob E. Davis, Edward Wang, Jonathan M. Zuidema, Yi‐Sheng Lu, Yu-Hwa Lo, Jason K. Sicklick, Michael J. Sailor, Partha Ray
Abstract
analyses of GIST-burdened mice that had been injected intravenously (IV) with aptamer-conjugated pSiNPs show extensive nanoparticle-to-tumor signal co-localization (>90% co-localization) compared to control particles. This provides an effective platform for which aptamer-conjugated pSiNP constructs can be used for the imaging of KIT-expressing cancers or for the targeted delivery of therapeutics.
Topics & Concepts
Conjugated systemAptamerDNAPorous siliconStromal cellNanotechnologyNanoparticleMaterials scienceSiliconCancer researchBiophysicsChemistryMolecular biologyMedicineBiologyBiochemistryOptoelectronicsPolymerComposite materialSilicon Nanostructures and PhotoluminescenceOptical Coatings and GratingsAdvanced biosensing and bioanalysis techniques