Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study
Romualdo Troisi, Francesco Galardo, Giarita Ferraro, Filomena Sica, Antonello Merlino
Abstract
The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.
Topics & Concepts
ChemistryTransferrinCisplatinAdductStereochemistryCrystallographyBiochemistryInternal medicineOrganic chemistryMedicineChemotherapyMetal complexes synthesis and propertiesDrug Transport and Resistance MechanismsDNA and Nucleic Acid Chemistry