Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development
Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita
Abstract
, the gene encoding hMOF, indicated that it is highly overexpressed in kidney tumors as part of a concerted gene coexpression program that can support high levels of chromosome segregation and cell proliferation. The linkage between MOF and tumor proliferation suggests that there are additional functions of MOF that remain to be discovered.
Topics & Concepts
BiologyHistone acetyltransferaseDNA damageHistoneCarcinogenesisStem cellCell biologyCancer researchCell growthDNA repairDNAGeneticsCancerHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationProtein Degradation and Inhibitors