Organocatalytic asymmetric synthesis of multifunctionalized α-carboline-spirooxindole hybrids that suppressed proliferation in colorectal cancer cells
Xiang‐Hong He, Xue‐Ju Fu, Gu Zhan, Nan Zhang, Xiang Li, Hongping Zhu, Cheng Peng, Gu He, Bo Han
Abstract
An asymmetric organocatalytic cascade reaction has been reported for the rapid assembly of multifunctionalized α-carboline-spirooxindole hybrids, which suppressed proliferation in colorectal cancer cells.
Topics & Concepts
ChemistryColorectal cancerHybridCascadeIsatinCancer researchCombinatorial chemistryCancerOrganic chemistryInternal medicineBotanyChromatographyBiologyMedicineSynthesis and bioactivity of alkaloidsSynthesis of Indole DerivativesAsymmetric Synthesis and Catalysis