Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses
Christopher A. Beaudoin, Arian R. Jamasb, Ali F. Alsulami, Liviu Copoiu, Andries J. van Tonder, Sharif Hala, Bridget P. Bannerman, S.E. Thomas, Sundeep Chaitanya Vedithi, Pedro Henrique Monteiro Torres, Tom L. Blundell
Abstract
MSP-1. Similarity to human proteins may reveal which pathways the spike protein is co-opting, while analogous non-human proteins may indicate shared host interaction partners and overlapping antibody cross-reactivity. These findings can help guide experimental efforts to further understand potential interactions between human and coronavirus proteins.
Topics & Concepts
BiologyMolecular mimicryDruggabilityComputational biologyCoronavirusEpitopePlasma protein bindingHomology modelingPeptide sequenceProtein–protein interactionSequence alignmentGeneticsCell biologyAntibodyCoronavirus disease 2019 (COVID-19)BiochemistryGeneEnzymeMedicineInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesComputational Drug Discovery Methods