Access to <i>N</i>−CF<sub>3</sub> Formamides by Reduction of <i>N</i>−CF<sub>3</sub> Carbamoyl Fluorides
Filip G. Zivkovic, Christian D.‐T. Nielsen, Franziska Schoenebeck
Abstract
Abstract The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N ‐trifluoromethylated formamides. The method involves the reduction of bench‐stable N CF 3 carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made N −CF 3 formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.
Topics & Concepts
FormamidesFormamideChemical spaceChemistryStereocenterCombinatorial chemistryMoleculeDrug discoveryOrganic chemistryEnantioselective synthesisBiochemistryCatalysisFluorine in Organic ChemistryInorganic Fluorides and Related Compounds