The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia
Yonglan Liu, Hyunbum Jang, Mingzhen Zhang, Chung‐Jung Tsai, Ryan Maloney, Ruth Nussinov
Topics & Concepts
breakpoint cluster regionChronic myelogenous leukemiaMyeloid leukemiaComputational biologyABLPeptideBinding siteChemistryK562 cellsGRB2Cancer researchLeukemiaCell biologyBiologyPhosphorylationReceptorSignal transductionBiochemistryGeneticsProto-oncogene tyrosine-protein kinase SrcTyrosine kinaseProtein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors