Thiadiazole based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and bioactivity evaluation
Huan Zhou, Yaxin Wen, Shao‐Hua Wang, Yan Liu, Baoqiong Li, Xuetao Xu
Topics & Concepts
PharmacophoreChemistryHydrogen bondCombinatorial chemistryAcarboseStereochemistryDocking (animal)Binding siteEnzymeLead compoundMolecular modelHydrophobic effectInhibitory postsynaptic potentialActive siteMolecular dynamicsFluorescenceStructure–activity relationshipEnzyme inhibitionBiological activityBroad spectrumMolecular bindingVirtual screeningEnzyme inhibitorChemical synthesisSynthesis and bioactivity of alkaloidsHIV/AIDS drug development and treatmentCancer therapeutics and mechanisms