Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism <i>via</i> AMPK/SIRT1/PGC-1α pathway in rats
Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang
Abstract
The activation of MC1R with BMS-470539 significantly attenuated EBI after SAH by suppressing the oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1α signaling pathway.
Topics & Concepts
AMPKMelanocortinMedicineAMP-activated protein kinaseSubarachnoid hemorrhageMetabolismReceptorEndocrinologyEnergy metabolismInternal medicineChemistryBiochemistryProtein kinase APhosphorylationDiet and metabolism studiesRegulation of Appetite and ObesityAdipose Tissue and Metabolism