Long-wavelength triggered iridium(<scp>iii</scp>) complex nanoparticles for photodynamic therapy against hypoxic cancer
Sheng-Nan Liu, Ziwei Wang, Zihan Wu, Hao Chen, Dongxia Zhu, Gungzhe Li, Mingming Yan, Martin R. Bryce, Yulei Chang
Abstract
A long-wavelength triggered cationic iridium(III) complex, Ir5, and its corresponding nanoparticles with the ability to generate type I and type II reactive oxygen species have been synthesised. The complex targets mitochondria and achieves an excellent photodynamic therapy effect in hypoxic cancer cells.
Topics & Concepts
Photodynamic therapyIridiumReactive oxygen speciesNanoparticleIrradiationChemistryCancerCancer therapyCancer cellBiophysicsCancer researchOxygenPhotochemistryNanotechnologyMaterials scienceBiochemistryMedicineBiologyCatalysisInternal medicineOrganic chemistryPhysicsNuclear physicsNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials