Sustained delivery of gemcitabine <i>via in situ</i> injectable mussel-inspired hydrogels for the local therapy of pancreatic cancer
Li Xu, Shengnan Tang, Huiquan Yang, Min Liang, Pengfei Ren, Dandan Wei, Jian He, Weiwei Kong, Peidang Liu, Tianzhu Zhang
Abstract
against BxPC-3 pancreatic cancer cells, bringing minimized side effects to systemic normal tissues. The current findings manifested that the release out of the localized delivery platform in a sustained pattern afforded a durable gemcitabine-based chemotherapy effect and inhibited tumor metastasis more persistently after intratumoral injection of the Gem@Gel system, thereby advancing the development of novel drug-loaded materials with properties not accessed previously.
Topics & Concepts
Pancreatic cancerGemcitabineIn vivoDrug deliverySelf-healing hydrogelsIn situCancerMaterials scienceIn vitroCancer therapyCancer researchBiomedical engineeringMedicineNanotechnologyInternal medicineBiologyChemistryBiochemistryPolymer chemistryBiotechnologyOrganic chemistry3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationNanoparticle-Based Drug Delivery