Catalytic Enantioselective Bromoaminocyclization and Bromocycloetherification
Hai-Tao Wang, Haijing Zhong, Xi Xu, Wei Xü, Xiaojian Jiang
Abstract
Abstract We apply a chiral anionic phase‐transfer system for the catalytic asymmetric bromoaminocyclization and bromocycloetherification of momo‐functional benzo‐cyclic alkenes. Various brominated tricyclic benzo‐heterocycles were produced with up to 99% yields and 99% enantiomeric excess. The resulting enantioenriched hexahydro‐benzoindoles are key building blocks of bioactive molecules. magnified image
Topics & Concepts
ChemistryEnantioselective synthesisCatalysisEnantiomerTricyclicEnantiomeric excessStereochemistryCombinatorial chemistryMoleculeOrganic chemistryVanadium and Halogenation ChemistryOxidative Organic Chemistry Reactions