Implantable aptamer–field-effect transistor neuroprobes for in vivo neurotransmitter monitoring
Chuanzhen Zhao, Kevin M. Cheung, Iwen Huang, Hongyan Yang, Nako Nakatsuka, Wenfei Liu, Yan Cao, Tianxing Man, Paul S. Weiss, Harold G. Monbouquette, Anne M. Andrews
Abstract
surfaces were coupled with synthetic oligonucleotide receptors (aptamers) to recognize and to detect the neurotransmitter serotonin. Aptamer-FET neuroprobes enabled femtomolar serotonin detection limits in brain tissue with minimal biofouling. Stimulated serotonin release was detected in vivo. This study opens opportunities for integrated neural activity recordings at high spatiotemporal resolution by combining these aptamer-FET sensors with other types of Si-based implantable probes to advance our understanding of brain function.
Topics & Concepts
AptamerIn vivoNeurotransmitterField (mathematics)Field-effect transistorNeuroscienceTransistorNanotechnologyBiologyMedicineMaterials scienceEngineeringElectrical engineeringBiotechnologyMolecular biologyMathematicsCentral nervous systemPure mathematicsVoltageNeuroscience and Neural EngineeringAnalytical Chemistry and SensorsAdvanced biosensing and bioanalysis techniques