Ruthenium-based assemblies incorporating tetrapyridylporphyrin panels: a photosensitizer delivery strategy for the treatment of rheumatoid arthritis by photodynamic therapy
Manuel Gallardo‐Villagrán, Lucie Paulus, Jean-Louis Charissoux, David Y. Léger, Pascale Vergne‐Salle, Bruno Therrien, Bertrand Liagre
Abstract
) metals in the center of TPyP impairs the effectiveness of PDT, showing no (Co) or reduced (Zn) photoactivity. A total of five metallacages with different structural characteristics have been evaluated, and our results suggest that the incorporation of PS in metalla-assemblies is not only an elegant method to increase solubility in biological media for TPyP but also appears to be an efficient hybrid system to treat RA by PDT.
Topics & Concepts
Photodynamic therapyPhotosensitizerRutheniumRheumatoid arthritisParamagnetismDiamagnetismSolubilityChemistryPhotochemistryMaterials scienceOrganic chemistryMedicineCatalysisMagnetic fieldQuantum mechanicsInternal medicinePhysicsPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsOcular Diseases and Behçet’s Syndrome