Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects
Kaan Küçükoğlu, Ulviye Acar Çevik, Hayrünnisa Nadaroğlu, İsmail Çeli̇k, Ayşen Işık, Hayrani Eren Bostancı, Yusuf Özkay, Zafer Asım Kaplancıklı
Topics & Concepts
ChemistryCarbonic anhydraseAcetazolamideBenzimidazoleOxadiazoleCarbonic anhydrase IIIC50AntioxidantDocking (animal)StereochemistryMTT assayCarbonic Anhydrase ICarbon-13 NMRLead compoundProton NMRActive siteIn vitroEnzymeCombinatorial chemistryBiochemistryOrganic chemistryNursingAnesthesiaMedicineEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesChemical Reactions and Mechanisms