Glutathione peroxidase mimics based on conformationally-restricted, <i>peri</i>-like, 4,5-disubstituted fluorene dichalcogenides
Kesar Jagdev, Damiano Tanini, Jack W. Lownes, Carlotta Figliola, Louise Male, Antonella Capperucci, Richard S. Grainger
Abstract
Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.
Topics & Concepts
FluoreneGlutathione peroxidaseChemistryPeroxidaseGlutathioneGPX3PeroxideBiochemistryEnzymeOrganic chemistryPolymerOrganoselenium and organotellurium chemistryOrganic Chemistry Cycloaddition ReactionsSulfur-Based Synthesis Techniques