Selection of an Optimal In Vitro Model to Assess P-gp Inhibition: Comparison of Vesicular and Bidirectional Transcellular Transport Inhibition Assays
Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda R. Hittle, Xiaoyan Chu
Topics & Concepts
P-glycoproteinTranscellularIn vitroParacellular transportVesicular transport proteinChemistryEffluxPharmacologyPolar surface areaQuinidineTransporterATP-binding cassette transporterMediated transportMultiple drug resistanceBiologyBiochemistryVesicleMembraneMoleculePermeability (electromagnetism)GeneOrganic chemistryAntibioticsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPregnancy and Medication Impact