Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir
Yinkai Duan, Hao Zhou, Xiang Liu, Sho Iketani, Meng-Meng Lin, Xiaoyu Zhang, Qucheng Bian, Haofeng Wang, Haoran Sun, Seo Jung Hong, Bruce Culbertson, Hiroshi Mohri, Maria I. Luck, Yan Zhu, Xiaoce Liu, Yuchi Lu, Xiuna Yang, Kailin Yang, Yosef Sabo, Alejandro Chavez, Stephen P. Goff, Zihe Rao, David D. Ho, Haitao Yang
Topics & Concepts
ProteaseMutationMutantDrug resistanceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyCoronavirus disease 2019 (COVID-19)VirusVirologyResistance mutationComputational biologyEnzymeRNAGeneticsChemistryBiochemistryReverse transcriptaseMedicineGeneInfectious disease (medical specialty)PathologyDiseaseSARS-CoV-2 and COVID-19 ResearchCRISPR and Genetic EngineeringRNA and protein synthesis mechanisms