Alpha radioimmunotherapy using <sup>225</sup>Ac-proteus-DOTA for solid tumors - safety at curative doses
Sarah M. Cheal, Michael R. McDevitt, Brian H. Santich, Mitesh Patel, Guangbin Yang, Edward K. Fung, Darren R. Veach, Meghan M. Bell, Afruja Ahad, Daniela Burnes Vargas, Blesida Punzalan, Nagavarakishore Pillarsetty, Hong Xu, Hong-Fen Guo, Sébastien Monette, Adam O. Michel, Alessandra Piersigilli, David A. Scheinberg, Ouathek Ouerfelli, Nai‐Kong V. Cheung, Steven M. Larson
Abstract
Ac]Pr, with the goal of delivering massive lethal doses of radiation to achieve a high probability of cure without toxicity.
Topics & Concepts
RadioimmunotherapyDOTACancer researchSolid tumorMedicineNuclear medicineRadiochemistryChemistryInternal medicineImmunologyCancerAntibodyChelationMonoclonal antibodyOrganic chemistryRadiopharmaceutical Chemistry and ApplicationsMedical Imaging Techniques and ApplicationsMedical Imaging and Pathology Studies