Bacteriophage AB-SA01 Cocktail in Combination with Antibiotics against MRSA-VISA Strain in an <i>In Vitro</i> Pharmacokinetic/Pharmacodynamic Model
Razieh Kebriaei, Katherine L. Lev, Kyle Stamper, Susan M. Lehman, Sandra Morales, Michael J. Rybak
Abstract
This study aimed to test the efficacy of bacteriophage-antibiotic combinations (BACs) in vitro in 24-h time-kill settings and in ex vivo simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic models for 96 h. BACs prevented the development of bacteriophage resistance, while some bacteriophage resistance emerged in bacteriophage-alone treatments. In addition, BACs resulted in an enhancement of bacterial eradication in SEV models. Our findings support the potential activity of BAC therapy for combating serious methicillin-resistant Staphylococcus aureus (MRSA) infections.
Topics & Concepts
BacteriophagePharmacodynamicsMicrobiologyAntibioticsPharmacokineticsStaphylococcus aureusBiologyIn vivoIn vitroVirologyPharmacologyBacteriaEscherichia coliBiotechnologyGeneticsGeneBacteriophages and microbial interactionsBacterial Identification and Susceptibility TestingMicrobial infections and disease research