Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness
Dominik Brücher, Vojtěch Franc, Sheena N. Smith, Albert J. R. Heck, Andreas Plückthun
Abstract
glycoengineering of expressed antibodies to optimize their efficacies, depending on the desired mode of action.
Topics & Concepts
GlycosylationAntibodyIn vivoFucosylationChinese hamster ovary cellGenetic enhancementBiologyGlycanCell cultureCancer researchGeneImmunologyMolecular biologyGlycoproteinBiochemistryGeneticsMonoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in InsectsGlycosylation and Glycoproteins Research