FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway
Zuhong He, Ming Li, Qiaojun Fang, Fu-ling Liao, Shengyu Zou, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Xiaoxiang Xu, Sen Chen, Yu Sun, Renjie Chai, Weijia Kong
Abstract
: AHL: age-related hearing loss; baf: bafilomycin A1; CD: common deletion; D-gal: D-galactose; GO: glucose oxidase; HC: hair cells; mtDNA: mitochondrial DNA; RAP: rapamycin; ROS: reactive oxygen species; TMRE: tetramethylrhodamine, ethyl ester.
Topics & Concepts
AutophagyBiologyPresbycusisReactive oxygen speciesCell biologyMitochondrionHair cellProgrammed cell deathMitochondrial DNAApoptosisHearing lossGeneticsInner earGeneAnatomyMedicineAudiologyHearing, Cochlea, Tinnitus, GeneticsCancer-related molecular mechanisms researchPlant Molecular Biology Research