Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
James P. C. Coverdale, Hugo A. van den Berg, Siavash Khazaipoul, Hannah E. Bridgewater, Alan J. Stewart, Claudia A. Blindauer
Abstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
Topics & Concepts
ZincExtracellularGenetic algorithmAlbuminChemistryBiochemistryBiologyGeneticsOrganic chemistryTrace Elements in HealthDrug Transport and Resistance MechanismsHeavy Metal Exposure and Toxicity