Analysis of <i>Streptomyces</i> Volatilomes Using Global Molecular Networking Reveals the Presence of Metabolites with Diverse Biological Activities
Jingyu Liu, Jody-Ann Clarke, Sean McCann, N. Kirk Hillier, Kapil Tahlan
Abstract
This study represents the first detailed analysis of Streptomyces volatilomes using MSHub/GNPS, which in combination with a routinely used conventional method led to many annotations. More VOCs could be annotated using MSHub/GNPS as compared to the conventional method, many of which have known antimicrobial, anticancer, and insect behavior-modulating activities.
Topics & Concepts
StreptomycesWorkflowComputational biologyGas chromatography–mass spectrometryBiologyBiochemical engineeringProcess (computing)Computer scienceChemistryMass spectrometryChromatographyBacteriaDatabaseGeneticsEngineeringOperating systemMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsAdvanced Synthetic Organic Chemistry