Association between sleep parameters and longitudinal shortening of telomere length
Jeong-Hwa Jin, Hyuk Sung Kwon, Seong Hye Choi, Seong‐Ho Koh, Eun Hye Lee, Jee Hyang Jeong, Jae‐Won Jang, Kyung Won Park, Eun‐Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Hyun‐Hee Park, Jungsoon Ha, Jong Eun Park, Myung Hoon Han
Abstract
BACKGROUND: The relationship between sleep parameters and longitudinal shortening of telomere length is unclear. This study aimed to investigate the relationship between sleep parameters and the shortening of leukocyte telomere length (LTL) over a year. METHODS: = 119 each). Multivariable logistic regression analyses were performed to determine independent relationships between faster shortening of LTL length and sleep parameters. RESULTS: = 0.007). Among the components of the PSQI, subjective measures of sleep quality, sleep latency, sleep duration, and sleep efficiency were significantly worse in participants with faster LTL shortening. Multivariate logistic regression analysis showed that sleep duration (per hour, OR = 0.831, 95% CI = 0.698-0.989), sleep latency (per minute, OR = 1.013, 95% CI = 1.002-1.024), global PSQI score (OR = 1.134, 95% CI = 1.040-1.236), shortest sleep duration (OR = 5.173, 95% CI = 1.563-17.126), and lowest sleep efficiency (OR = 7.351, 95% CI = 1.943-27.946) were independently associated with faster LTL shortening. CONCLUSIONS: Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.