<i>Mycoplasma genitalium</i> Antimicrobial Resistance in Community and Sexual Health Clinic Patients, Auckland, New Zealand
Anna Vesty, Gary McAuliffe, Sally Roberts, Gillian Henderson, Indira Basu
Abstract
M anagement of Mycoplasma genitalium infections is challenging because the limited treatment options have been affected by rapidly evolving resistance to antimicrobial drugs. Molecular approaches are the preferred method of M. genitalium detection, and resistance is determined genotypically. 23S rRNA mutations are associated with macrolide resistance and azithromycin treatment failures (1-3), whereas fluoroquinolone resistance is associated with mutations in the quinolone resistance-determining region, specifically in the gyrA and parC genes (4).
Topics & Concepts
Mycoplasma genitaliumSexual health clinicAntibiotic resistanceMedicineReproductive healthCommunity healthInternal medicineRetrospective cohort studyGenotypeAntimicrobialDrug resistanceMen who have sex with menMicrobiologyGynecologyFamily medicineBiologyAntibioticsPublic healthEnvironmental healthHuman immunodeficiency virus (HIV)NursingGeneticsSyphilisChlamydia trachomatisPopulationGeneReproductive tract infections researchBlood groups and transfusionMicrobial infections and disease research