Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy
Heba A. Ibrahim, Hanan M. Refaat
Abstract
Abstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. Conclusion The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.
Topics & Concepts
BenzimidazoleLinkerChemistryCancerCombinatorial chemistryCancer therapyAnticancer drugStereochemistryComputational biologyPharmacologyDrugMedicineBiologyComputer scienceInternal medicineOrganic chemistryOperating systemSynthesis and biological activityClick Chemistry and ApplicationsBioactive Compounds and Antitumor Agents