The Legionella pneumophila Metaeffector Lpg2505 (MesI) Regulates SidI-Mediated Translation Inhibition and Novel Glycosyl Hydrolase Activity
Ashley M. Joseph, Adrienne E. Pohl, Theodore J. Ball, Troy G. Abram, David K. Johnson, Brian V. Geisbrecht, Stephanie R. Shames
Abstract
Legionella pneumophila , the etiological agent of Legionnaires’ disease, employs an arsenal of hundreds of Dot/Icm-translocated effector proteins to facilitate replication within eukaryotic phagocytes. Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The metaeffector Lpg2505 is essential for L. pneumophila intracellular replication only when its cognate effector, SidI, is present.
Topics & Concepts
Legionella pneumophilaEffectorBiologyTranslation (biology)IntracellularCell biologyLegionellaMicrobiologyEukaryotic translationBiochemistryBacteriaGeneticsGeneMessenger RNALegionella and Acanthamoeba researchNeutrophil, Myeloperoxidase and Oxidative MechanismsBacterial biofilms and quorum sensing