Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation
Md Masud Parvez, Abdul Basit, Parth B. Jariwala, Zsuzsanna Gáborik, Emese Kis, Scott Heyward, Matthew R. Redinbo, Bhagwat Prasad
Topics & Concepts
IrinotecanMetaboliteGlucuronidationPharmacologyMetabolismChemistryToxicityTransporterBiochemistryBiologyEnzymeMicrosomeCancerColorectal cancerOrganic chemistryGeneticsGeneCancer therapeutics and mechanismsDrug Transport and Resistance MechanismsAntibiotics Pharmacokinetics and Efficacy