Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes
Long Jin, Xinglong Zhang, Rui-Li Guo, Meng‐Yue Wang, Yaru Gao, Yong‐Qiang Wang
Abstract
A direct and efficient palladium-catalyzed oxidative dehydrogenative fluoroalkoxylation of benzaldehydes is reported here for the first time. The method features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The approach should find broad applications in drug synthesis and discovery processes.
Topics & Concepts
ChemistryPalladiumCatalysisFunctional groupCombinatorial chemistryScope (computer science)Substrate (aquarium)Atom economyReaction conditionsOrganic chemistryComputer scienceProgramming languageOceanographyPolymerGeologyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions