<i>Ex Vivo</i> Herpes Simplex Virus Reactivation Involves a Dual Leucine Zipper Kinase-Dependent Wave of Lytic Gene Expression That Is Independent of Histone Demethylase Activity and Viral Genome Synthesis
Abigail L. Whitford, Corinne A. Clinton, Emily B. Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Abstract
occurs via mechanisms that are distinct from production replication, namely, lytic gene expression that is independent of viral DNA replication and histone demethylase activity. The identification of a DLK-dependent wave of lytic gene expression from sensory ganglia will ultimately permit the development of novel therapeutics that target lytic gene expression and prevent the earliest stage of reactivation.
Topics & Concepts
BiologyLytic cycleHerpes simplex virusVirologyHistoneVirusGeneDemethylaseGene expressionEx vivoLeucine zipperIn vivoGeneticsTranscription factorHerpesvirus Infections and TreatmentsToxin Mechanisms and ImmunotoxinsDermatology and Skin Diseases