A Genomic Perspective on the Near-term Impact of Doxycycline Post-exposure Prophylaxis on <i>Neisseria gonorrhoeae</i> Antimicrobial Resistance
Tatum D. Mortimer, Yonatan H. Grad
Abstract
Pre-existing tetracycline resistance in Neisseria gonorrhoeae limits the effectiveness of post-exposure prophylaxis (PEP) with doxycycline against gonorrhea, and selection for tetracycline resistance may influence prevalence of multi-drug resistant strains. Using genomic and antimicrobial susceptibility data from N. gonorrhoeae, we assessed the near-term impact of doxycycline PEP on N. gonorrhoeae resistance.
Topics & Concepts
DoxycyclineNeisseria gonorrhoeaeMedicineAntimicrobialAntibiotic resistanceMicrobiologyTerm (time)VirologyAntibioticsBiologyQuantum mechanicsPhysicsReproductive tract infections researchBacterial Infections and VaccinesSyphilis Diagnosis and Treatment