Role of Phosphoinositide 3-Kinase in Regulation of NOX-Derived Reactive Oxygen Species in Cancer
Ali A. Akhiani, Anna Martner
Abstract
Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species (ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis. Enhanced NOX activity has been associated with aberrant activation of oncogenic cascades such as the phosphoinositide 3-kinase (PI3K) signaling pathway, which is upregulated in several malignancies. In this review, we examine the role of PI3K on the regulation of NOX-induced ROS formation in cancer.
Topics & Concepts
Reactive oxygen speciesNOxPhosphoinositide 3-kinasePI3K/AKT/mTOR pathwayCarcinogenesisNADPH oxidaseChemistryCell biologySignal transductionKinaseCancer researchBiochemistryBiologyGeneCombustionOrganic chemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsImmune Response and Inflammation