Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling
Chengliang Li, Hong Xin, Yingpeng Shi, Jianjun Mu
Topics & Concepts
Oxidative stressProtein kinase BCardioprotectionGSK-3Reperfusion injurySignal transductionCell biologyGlycogen synthasePI3K/AKT/mTOR pathwayInflammationApoptosisGSK3BDownregulation and upregulationChemistryMedicineIschemiaPharmacologyEndocrinologyPhosphorylationInternal medicineBiologyBiochemistryGeneGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stressCardiac Ischemia and Reperfusion