Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance
Reyhane Javanshir, Moones Honarmand, Mehran Hosseini, Mina Hemmati
Abstract
Abstract Background Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Methods Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined. Results results showed a significant decrease in the level of liver MDA ( P = 0.001), fasting blood glucose ( P = 0.0001), HOMA-IR ( P = 0.0001), ALT ( P = 0.0001), AST ( P = 0.0001), urea ( P = 0.02), Triglycerides ( P = 0.002), Total cholesterol ( P = 0.0001), PAB ( P = 0.0001) and AIP ( P = 0.001) and in contrast a significant increase total antioxidant capacity ( P = 0.02), insulin ( P = 0.03), Body weight ( P = 0.0001) and vitamin D ( P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group ( P = 0.18), LDL-C ( P = 0.43), creatinine ( P = 0.09) and HDL-C ( P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats. Conclusion The results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.