Diaphragm muscle fibrosis involves changes in collagen organization with mechanical implications in Duchenne muscular dystrophy
Ridhi Sahani, C. Hunter Wallace, Brian K. Jones, Silvia S. Blemker
Abstract
, Duchenne muscular dystrophy model, mice revealed that collagen fibers in the epimysium are oriented transverse to muscle fibers, with age- and disease-dependent changes in collagen arrangement. Finite-element models generated from these images predicted that changes in collagen arrangement during disease progression influence the mechanical properties of the extracellular matrix. Thus, changes in collagen fiber-level structure are implicated on tissue-level properties during fibrosis.
Topics & Concepts
Extracellular matrixDuchenne muscular dystrophyDiaphragm (acoustics)FibrosisAnatomyMuscular dystrophyPathologyDecellularizationChemistryMaterials scienceMedicineInternal medicineBiochemistryLoudspeakerAcousticsPhysicsMuscle Physiology and DisordersExercise and Physiological ResponsesTissue Engineering and Regenerative Medicine