A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy
Georgios Athanasiadis, Joeri Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Abstract
Significance The ability to extract multigenerational family relationships from large-scale population cohorts provides a powerful means to understand the heritability of a wide range of diseases and their genetic relationships to each other. By showing how the heritability of broad diagnostic categories changes over time and how said categories are related on the genetic level, our analysis of the Danish genealogy and linked national patient registers illustrates the vast potential of this resource in current biomedical research.
Topics & Concepts
DanishHeritabilityGenealogyResource (disambiguation)PopulationScale (ratio)GeographyDemographyEvolutionary biologyBiologyComputer scienceHistoryCartographySociologyLinguisticsPhilosophyComputer networkGenetic Associations and EpidemiologyBiomedical Text Mining and OntologiesGenomics and Rare Diseases