Multiscale conformational dynamics probed by time‐resolved circular dichroism from seconds to picoseconds
F. Hache, Pascale Changenet‐Barret
Abstract
Time-resolved circular dichroism has been developed for a few decades to investigate rapid conformational changes in (bio)molecules. In our group, we have come up with several experimental set-ups allowing us to study pico-nanosecond local phenomena in molecular systems as well as much slower effects occurring in proteins and DNA in the folding processes. After an overview of the worldwide realizations in this domain, we present emblematic experiments that we have carried out, spanning time domain from picoseconds to seconds.
Topics & Concepts
PicosecondNanosecondChemistryCircular dichroismFolding (DSP implementation)Vibrational circular dichroismChemical physicsMolecular dynamicsMoleculeTime domainDynamics (music)Protein foldingCrystallographyOpticsComputational chemistryPhysicsElectrical engineeringLaserAcousticsEngineeringOrganic chemistryComputer scienceComputer visionBiochemistrySpectroscopy and Quantum Chemical StudiesDNA and Nucleic Acid ChemistryMolecular spectroscopy and chirality