The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system
Xiansheng Ye, Wenjing Tian, Guanghui Wang, Kuan Lin, Shu-Xiu Zhu, Yiyuan Xia, Binlian Sun, Xiji Shu, Wei Liu, Haifeng Chen
Abstract
The food and medicine homologous traditional Chinese medicines (FMHCMs) have attracted great attention for their high nutritional and broad medicinal value, especially for the neuroprotective effects on nervous system. In this review, the neuroprotective constituents of FMHCMs from Leguminosae species, including <i>Astragalus membranaceus</i> (<i>Astragalus membranaceus</i> (Fisch.) Bge.), <i>Glycyrrhiza uralensis</i> Fisch. (<i>Glycyrrhiza inflata</i> Bat. or <i>Glycyrrhiza glabra</i> L.), <i>Cassia obtusifolia</i> L. (<i>Cassia tora</i> L.), <i>Vigna umbellata</i> Ohwi et Ohashi (<i>Vigna angularis</i> Ohwi et Ohashi), <i>Glycine max</i> (L.) Merr., <i>Sophora japonica</i> L., <i>Canavalia gladiata</i> (Jacq.) DC., <i>Pueraria lobata</i> (Willd.) Ohwi, and <i>Dolichos lablab</i> L. are summarized. As a result, 25 bioactive constituents are found to exert neuroprotective effects on nervous system through reducing oxidative stress and neuroinflammation responses, protecting nerve cell from apoptosis, and improving mitochondrial function and blood flow to the brain. The purpose of the review is to provide comprehensively and systematically information about the neuroprotective constituents of FMHCMs from Leguminosae species, and lay the basis for the future developments of FMHCMs from Leguminosae species.