Photoredox-Catalyzed Difunctionalization of Unactivated Olefins for Synthesizing Lactam-Substituted <i>gem</i>-Difluoroalkenes
Jie Shi, Li‐Yun Guo, Qu-Ping Hu, Yutao Liu, Qing Li, Fei Pan
Abstract
Herein, the synthesis of lactam-substituted gem-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Brønsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/β-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or urea-substituted gem-difluoroalkenes with good functional group tolerance and high yields.
Topics & Concepts
ChemistryPhotoredox catalysisCatalysisIntermolecular forceCombinatorial chemistryIntramolecular forceFunctional groupLactamOrganic chemistryMoleculePhotocatalysisPolymerFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods