Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron
Peng Gao, Joseph. W. Graham, Wen‐Liang Zhou, Jin‐Young Jang, Sergio Angulo, Salvador Durá-Bernal, Michael L. Hines, William W. Lytton, Srdjan D. Antic
Abstract
In cortical pyramidal neurons, we recorded glutamate-mediated dendritic plateau potentials with voltage imaging and created a computer model that recreated experimental measures from dendrite and cell body. Our model made new predictions, which were then tested in experiments. Plateau potentials profoundly change neuronal state: a plateau potential triggered in one basal dendrite depolarizes the soma and shortens membrane time constant, making the cell more susceptible to firing triggered by other afferent inputs.
Topics & Concepts
Dendritic spikeSomaNeuroscienceDendrite (mathematics)Membrane potentialApical dendritePlateau (mathematics)GlutamatergicNeuronBiophysicsChemistryElectrophysiologyGlutamate receptorExcitatory postsynaptic potentialBiologyInhibitory postsynaptic potentialGeometryMathematical analysisBiochemistryReceptorMathematicsNeural dynamics and brain functionNeurobiology and Insect Physiology ResearchOlfactory and Sensory Function Studies