Stereoselective transition metal-catalyzed [(2+2)+1] and [(2+2)+2] carbocyclization reactions using 1,6-enynes with 1,1-disubstituted olefins: construction of quaternary centers
Ridge Michael P. Ylagan, Zhu Yu, P. Andrew Evans
Abstract
highlights key developments in stereoselective semi-intramolecular metal-catalyzed [(2+2)+1] and [(2+2)+2] carbocyclizations of 1,6-enynes containing 1,1-disubstituted alkenes, which produce cycloadducts with quaternary stereogenic centers. The insights gleaned from these examples provide a blueprint for developing more general carbocyclization strategies with challenging polysubstituted olefins.
Topics & Concepts
StereoselectivityCatalysisTransition metalChemistryMedicinal chemistryCombinatorial chemistryMetalStereochemistryOrganic chemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis