Bottleable NiCl<sub>2</sub>(dppe) as a catalyst for the Markovnikov-selective hydroboration of styrenes with bis(pinacolato)diboron
Toru Hashimoto, Toshiya Ishimaru, Keisuke Shiota, Yoshitaka Yamaguchi
Abstract
Although transition-metal-catalysed hydroboration reactions of alkenes have been extensively studied, only three examples using Ni complexes have been reported so far. In this study, we have examined hydroboration reactions of alkenes using Ni/phosphine complexes. The commercially available and bottleable complex NiCl2(dppe) (dppe = 1,2-bis(diphenylphosphino)ethane) serves as a catalyst for the highly Markovnikov-selective hydroboration of styrene derivatives that affords the desired Markovnikov products in high yield.
Topics & Concepts
HydroborationChemistryMarkovnikov's ruleCatalysisCombinatorial chemistryOrganic chemistryRegioselectivityOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsChemical Synthesis and Analysis