Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines
Shanti Priya Vemuluri, Vijaya Laxmi Somarapu, Laxminarayana Eppakayala
Abstract
We have developed a new series of various aryl amide derivatives of thiazole-benzothaizole-pyrimidines (13a-j). Their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, the in vitro anticancer properties of newly derivative compounds 13a-j were investigated against four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing of MTT assay, and were compared with etoposide used as standard reference. Most of the tested compounds were displayed moderate to good anticancer activities than etoposide. The in vitro assay results indicated that compounds 13a, 13b, 13c and 13d were possessed more potent activity as compared with standard. One of the compounds like 13a displayed superior anticancer activity.