Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation
Frederick Guzman, Yasamin Fazeli, Meagan Khuu, Kelsey Salcido, Sarah Singh, Claudia A. Benavente
Abstract
Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs.
Topics & Concepts
EpigeneticsChromatinRetinoblastoma proteinBiologyHistoneDNA methylationNucleosomeRegulatorChromatin remodelingCell biologyRetinoblastomaTranscriptional regulationHistone methylationTranscription factorCell cycleGeneticsGeneGene expressionEpigenetics and DNA MethylationChromatin Remodeling and CancerCancer-related Molecular Pathways